• 关键词：致癌性  防锈水

• 基金项目：

• 王达
• 中国科学院上海细胞生物学研究所

• 王蘅文
• 中国科学院上海细胞生物学研究所

• 摘要：对使用国产防锈水(主要成分为亚硝酸钠和三乙醇胺)的一个工厂进行肿瘤流行病学调查,发现该厂人员恶性肿瘤发病率略有增加。经长期给大白鼠饮用防锈水实验证明,该法可导致大鼠胰腺腺泡增生和不典型增生并能诱发出对照动物所没有的胰腺癌,同时还可引起胃粘膜的增生和胃乳头状瘤。

• Abstract：Rustproof fluid" is widely employed in machining industry as a lubricating agent with rust-preventing property. It is generally suspected to be able to produce carcinogenic agents in vivo or in vitro. Preliminary epidemiological survey among workers of machining industry revealed slight increase in incidences of various cancers. Thus chronic ingestion experiments on Wistar rats were carried out to examine its carcinogenic risk.After continuous ingestion of "rustproof fluid" as drinking water for 2 years, 11/40 malignant tumors were found among experimental rats and 9/40 among them were pancreatic adenocarcinomas. Hyperplasia, and atypical hyperplasia of pancreatic acini were found in both groups, but were absent in the controls. There seemed to be certain dose-response relationship regarding the pancreatic carcinogenicity of the fluid. Hyperplasia, degeneration, ulceration and hemorrhage of the gastric mucosa were also found after prolonged ingestion of "rustproof fluid".

• Key words：carcinogenicity  rustproof fluid

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