• 关键词：抗药性  显性度  杂合子  基因频率  抗性治理

• 基金项目：中国科学院自然科学基金资助课题

• 唐振华
• 中国科学院上海昆虫研究所

• 韩启发
• 中国科学院上海昆虫研究所

• 摘要：通过计算机模拟,研究了在R基因频率和种群大小的三种不同组合情况下,害虫抗性杂合于在用药或不用药时对抗性进化的影响.模拟结果表明,1)在任何组合中不用药时R基因的衰退是一个缓慢的过程,除非(RR)和(RS)遗传型的生物适合度很低.若R基因的显性越高,生物适合度越低,则抗性基因衰退越快.2)用杀死全部或绝大多数杂合子的剂量,并有少量敏感个体迁入时,抗性可被控制.但抗性一旦很明显,则此策略不再有效.

• Abstract：The effects of changes of heterozygote in the absence and presence of insecticides and the degree of its dominance on evolution in three different combinations of R allel frequency and population size were investigated by computer simulation. The results showed that in all combinations, the reversion of R allel in the absence of insecticide was a slow process except for RR and RS phenotypes with low biotic fitness. The lower the fitness value, the faster the resistance reversed. Evolution of resistance to insecticides could be controlled when high dosage of insecticide sufficient to kill all or most heterozygote was used in the presence of a small influx of susceptible immigrants. Once resistances was obvious, it would make this strategy no longer effective.

• Key words：resistance  degree of dominance  heterozygote  frequency of gene  resistance management

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