• 关键词：肠酯酶  抑制作用  杀虫剂

• 基金项目：国家自然科学基金资助课题

• 陈巧云
• 中国科学院上海昆虫研究所

• 姜家良
• 中国科学院上海昆虫研究所

• 邓启荣
• 中国科学院上海昆虫研究所

• 侯能俊
• 中国科学院上海昆虫研究所

• 林国芳
• 中国科学院上海昆虫研究所

• 摘要：比较了速灭杀丁、杀螟松和增效剂NIA₁₆₃₈₈的单剂和混剂在离体与整体条件下对大鼠肠脂酶同工酶的抑制作用.结果表明,大鼠肠至少有10条酯酶带,主要由羧酸酯酶组成.杀螟松能强烈抑制羧酸酯酶活力,而速灭杀丁与NIA₁₆₃₈₈在处理2h时呈现抑制作用,而随处理时间的增加酶活力有恢复的现象,羧酸酯酶的这种抑制作用同杀虫剂的剂量有关.

• Abstract：The inhibition of rat intestine esterase by sumithion fenvalerate and NIA16388 has been studied in vivo and in vitro. The results showed that there are at least 10 esterase bands in rat intestine, most of which have carboxylesterase activity. Sumithion strongly inhibited the esterase activity at various treated durations, while the inhibition was found only at first two hours for fenvalerate and NIA16388. The degree of inhibition depended on insecticide dosage. The relationship between the inhibition of carboxylesterase and the toxicity of insecticide was discussed.

• Key words：intestine esterase  insecticide.

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