研究论文
庞素珍,陈云俊,秦静芬,林治焕,杨福愉.克山病病区低硒粮喂养的豚鼠红细胞内Na+浓度变化的研究[J].环境科学学报,1992,12(4):461-465
克山病病区低硒粮喂养的豚鼠红细胞内Na+浓度变化的研究
- STUDY ON CHANGES IN INTRACELLULAR Na+ CONCENTRATION OF ERYTHROCYTES FROM GUINEA PIGS REARED ON LOW Se CEREALS GROWN IN ENDEMIC AREAS OF KESHAN DISEASE
- 基金项目：
- 作者
- 单位
- 庞素珍
- 中国科学院生物物理研究所, 北京 100080
- 陈云俊
- 中国科学院生物物理研究所, 北京 100080
- 秦静芬
- 中国科学院生物物理研究所, 北京 100080
- 林治焕
- 中国科学院生物物理研究所, 北京 100080
- 杨福愉
- 中国科学院生物物理研究所, 北京 100080
- 摘要：豚鼠分别喂以克山病病区粮（低硒）和非病区粮（硒含量正常）,借助合成的DY（PPP）2-7位移试剂用XL-400NMR谱仪直接测试完整红细胞内Na+的NMR谱,并定量计算细胞内Na+浓度,发现低硒的病区粮饲养的豚鼠红细胞内Na+浓度显著高于正常组;病区粮喂养的豚鼠红细胞在老化条件下细胞溶血比非病区严重。
- Abstract：Intracellular Na+ concentration of red blood cells from guinea pigs reared on low-Se cereals grown in endemic areas of Keshan Disease (KD) was measured by NMR technique and shift reagent Dy (P3O10)2-7. The results showed that the intracellular Na+ concentration was obviously higher than that of the control. In comparison with control, a large increase in intracellular Na+ concentration of guinea pig erythrocytes reared on low-Se cereals was observed following ageing (37℃ for 1 to 2 days). The study also suggested Se-deficiency could induce destabilization of red blood cell membrane.
- Key words：guinea pig erythrocyte low selenium Na+ NMR
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