• 关键词：发光细菌  暗变种  致突变效应

• 基金项目：

• 顾宗濂
• 中国科学院南京土壤研究所,210008

• 谢思琴
• 中国科学院南京土壤研究所,210008

• 周德智
• 中国科学院南京土壤研究所,210008

• 摘要：从明亮发光杆菌T₃小种(Photobacterium Phosphoreum T₃ sp.)分离到的自发暗变种(K变种)T9171菌株对三种化合物呈致突阳性反应,对二种化合物呈可疑阳性.发光细菌暗变种对遗传毒性化合物致突效应的灵敏度高于Ames试验和哺乳动物致癌试验,可望成为一种简易灵敏的测试环境致突变物的短期生物学试验方法.

• Abstract：The positive mutagenic response to four chemicals and doubtable positive mutagenic response to one chemical were demonstrated by a spontaneous dark mutant (K mutant), strain T9171, isolated from Photobacterium phosphoreum T₃ spp. Mutagenic response of the Photobacteria' s dark mutant has higher sensitivity to genotoxic chemicals as compared with mutagenic test of Salmo-nella/microsome (Ames test) and carcinogenic test of mammal.

• Key words：dark mutant  mutagenic effect  photobacteria

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