研究论文
赵元慧,王连生,于红霞,高鸿.取代芳烃对发光菌的毒性及定量结构与活性相关[J].环境科学学报,1993,13(4):442-449
取代芳烃对发光菌的毒性及定量结构与活性相关
- TOXICITY OF SUBSTITUTED AROMATIC COMPOUNDS TO PHOTOBACTERIUM PHOSPHOREUM AND QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS
- 基金项目：国家自然科学基金资助课题
- 作者
- 单位
- 赵元慧
- 南京大学环境科学系,210008
- 王连生
- 南京大学环境科学系,210008
- 于红霞
- 南京大学环境科学系,210008
- 高鸿
- 南京大学化学系
- 摘要：通过测定取代芳烃对发光菌毒性,用Free-Wilson法和分子连接性法研究了取代芳烃结构与活性的相关性,取代基的毒性顺序为:-Br>-COOH>-NO2≈-Cl>-CH3>-NH2.建立了EC50与LC50的相关性,并预测了一些化合物的LC50值,结果和实测值符合较好.
- Abstract：The toxicities of substituted aromatic compounds to photobacterium phos-phoreum were studied. Relationships between structure and activity of organic compounds were examined by Free-Wilson and Molecular connectivity methods. The order of toxicity contributions for six substituents investigated is as follows.-Br>-COOH>-NO2≈-Cl>-CH3 >-NH2. The relationship between EC50 and LC50 was established. LC50 values were predicted by the EC50 values. The predicted LC50 values are close to those observed.
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