• 关键词：生殖毒性  浓缩铀  精子  精原细胞  DNA链断裂  骨骼畸形

• 基金项目：国家自然科学基金

• 朱寿彭
• 苏州医学院放射医学系,苏州 215007

• 胡启跃
• 苏州医学院放射医学系,苏州 215007

• 伦明跃
• 苏州医学院放射医学系,苏州 215007

• 摘要：在不同水平浓缩铀²³⁵UO₂F₂内污染诱发机体生殖毒性的研究中,观察到浓缩铀可诱发精子畸形,主要呈现双头和无钩精子。浓缩铀诱发精原细胞染色体畸变,则以染色体断片为主,对初级精母细胞可产生染色体断片和易位,出现多价体。浓缩铀可致精子DNA链断裂,其断裂片段则可随²³⁵UO₂F₂摄入量的加大而增多,浓缩铀引起遗传物质的损伤,可诱发胎鼠显性致死突变和骨骼畸形增生,而其诱发骨骼畸形的

• Abstract：A study on the reprduction toxicity exposed to internal contamination of enriched ura-nium at different levels is reported.Abnormalities in sperm induced by ²³⁵UO₂F₂,bicapsand non-hock sperms are found to be predominant.Enriched uranium can in-duce chromosome aberrations in germ cells.Among the type of chromosome aberrations ofspermatogonium'chromosome breakage has shown to be predominant.At the same timechromosome fragment and translocation of primary spermatocyte have also shown to be in-duced by ²³⁵UO₂F₂.Enriched uranium can result in sperm DNA strand breakage,Thelevels of sperm DNA strand breakage from treated mice increase with the increasing dosesof ²³⁵UO₂F₂.It is to be noted that enriched uranium can damage genetic materials andcause an increase in the dominant lethality and skeletal abnormalities in offspring.The rela-tionship between incidence of dominant skeletal abnormalities in offspring (B)and injecteddOses of ²³⁵UO₂F₂(I)in testes can be expressed by the equation:B=28.84+0,84I.

• Key words：repteduction toxicity  enriched uranium  sperm  spermatogonium  pri-mary spermatocyte  DAN strand breakage  skeletal abnormalitles

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