• 关键词：有机磷化合物诱导的迟发性神经毒性(OPIDP)  三甲基苯基磷酸酯(TOCP)  神经病损靶标酯酶(NTE)

• 基金项目：国家自然科学基金

• 伍一军
• 中国科学院动物学研究所,北京 100080

• 冷欣夫
• 中国科学院动物学研究所,北京 100080

• 摘要：以成年产卵来航母鸡为试验动物,研究了三甲基苯基磷酸酯(Tri-o-CresylPhos-phate,TOCP)诱导的迟发性神经毒性。试验发现,母鸡口服TOCP(750mg/kg)后,经过大约8-10d的潜伏期开始出现中毒症状,其表现为以步态失调为主要特征的运动障碍呈进行性加重,至第21d开始便发展为瘫痪,对鸡脑神经病损靶标酯酶(NeuropathyTargetEnzyme,NTE)活性的测定表明,有机械诱导的迟发性神经毒性(Organophosphate-InducedDelayedPoly

• Abstract：A study on delayed neuropathy induced by tri-o-cresyl phosphate(TOCP)in adult lay-ing white Leghorn hens has been carried out.. The results showed that the clinical symptomcan not be seen until 8-10 days after the treatment of a single oral 750 mg/kg dose ofTOCP, and its main feature is ataxia in progress, Almost dosed hens became paralysis at 3weeks after dosing. The activity of neuropathy target enzyme(NTE)of dosed hen brainwas inhibited and the maximum inhibition at 3 days(the inhibition rate is 91;15%, P<0.01), and then NTE activity was somewhat recovered, but the inhibition rate is 74.87%(P<0.01)at 1 week and 8.22% at 4 weeks, respectively. Therefore, the relationship be-tween the inhibition of NTE and organophosphate-induced delayed polyneuropathy(OPIDP)is not positive. It is possible that OPIDP had been triggered in the hen at 24 hoursafter treatment with TOCP, In addition, the decrease of body weight of the hens had alsobeen observed in the experiment.

• Key words：organophosphate-induced delayed polyneuropathy(OPIDP)  tri-o-cresyl phosphate(TOCP)  neuropathy target enzyme(NTE )

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