研究论文
竺乃恺,张朝,夏希娟,杜秀英.1-硝基芘和多环芳烃联合致突变性的研究[J].环境科学学报,2000,20(5):612-615
1-硝基芘和多环芳烃联合致突变性的研究
- The Research on the joint mutagenicity of mixtures of 1-nitropyrene and nitro-PAHs
- 基金项目：国家自然科学基金(29837180);中国科学院资助(KZ951B/20906)
- 作者
- 单位
- 竺乃恺
- 中国科学院生态环境研究中心, 北京100085
- 张朝
- 中国科学院生态环境研究中心, 北京100085
- 夏希娟
- 中国科学院生态环境研究中心, 北京100085
- 杜秀英
- 中国科学院生态环境研究中心, 北京100085
- 摘要：测定了1-硝基芘(1-NP)和其它(硝基—)多环芳烃对Ames试验的6个菌株(TA98, TA100, YG1021, YG1024, YG1026, YG1029)的单一和联合致突变性.1, 6二硝基芘(1, 6-DNP)、1-硝基芘(1-NP)和2-硝基芴(2-NF)的单一致突变性都为阳性, 且致突变性依次减弱;而其他PAHs样品均表现为阴性.6种菌株对, 1, 6-DNP和1-NP的敏感性依次为YG1024, YG1021, TA98, YG1026, YG1029, TA100;而它们对2NF的敏感性稍有差别.联合致突变性实验结果表明共存的1, 6-DNP和2-NF对1-NP的致突变性有不同程度的增加, 而共存的PAHs对1-NP的致突变性却有不同程度的抑制作用.
- Abstract：The mutagenicities of 1-nitropyrene(1-NP), 2-nitrofluorene(2-NF), 1, 6-dinitropyrene(1, 6-DNP), and five PAHs on Salmonella typhimurium TA98, TA100, YG1021, YG1024, YG1026, YG1029 were studied.The results showed that 1, 6-DNP is the most potent mutagen, next is 1-NP and the last is 2-NF;However, the mutagenicities of all PAHs tested are negative.The orders of sensitivity for six strains to both of 1-NP and 1, 6-DNP is YG1024, YG1021, TA98, YG1026, YG1029, TA100, but it is not for 2-NF.The results of the joint mutagenicity of the mixtures of 1-NP and each of NO-2-PAHs showed that 2-NF and 1, 6-DNP strengthened the mutagenicity of 1-NP, but inhibited by every PAHs.
- Key words：NP, NO 2-PAHs ames test joint mutagenicity sensitivity
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