环境化学
杜青平,贾晓珊,李适宇,孟紫强.二氧化硫对大鼠血红细胞膜流动性及其酶活性的影响[J].环境科学学报,2007,27(9):1504-1508
二氧化硫对大鼠血红细胞膜流动性及其酶活性的影响
- Effects of SO2 on membrane fluidity and enzyme activities of rat erythrocytes
- 基金项目：国家自然科学基金资助项目(No.30230310);山西省自然科学基金资助项目(No.20031092)
- 作者
- 单位
- 杜青平
- 1. 广东工业大学环境科学与工程学院 广州 510006; 2. 中山大学环境科学与工程学院 广州 510275
- 贾晓珊
- 中山大学环境科学与工程学院 广州 510275
- 李适宇
- 中山大学环境科学与工程学院 广州 510275
- 孟紫强
- 山西大学环境医学和毒理学研究所 太原 030006
- 摘要：以二氧化硫(SO2)吸入后大鼠血红细胞膜为研究对象,测定了血红细胞膜流动性与定位于膜上及与膜特性有关的各种酶活性的影响.结果显示,SO2吸入后大鼠的膜脂流动性降低,膜脂质过氧化程度加重,膜结合酶SOD、Na+-K+-ATPase和Ca2+-Mg2+-ATPase活性降低,胞内酶LDH在血浆中的含量升高.以上结果表明,SO2吸入引起了红细胞膜组分分布和功能的改变,使膜的通透性升高.SO2对生物膜结构和功能的损伤是其毒性作用的起点.
- Abstract：The cytomembrane is a critical cellular structure.Every change of cellular function is related to the cytomembrane.In order to explore the effects of SO2 on the cytomembrane,the membrane fluidity and the enzyme activities of rat erythrocytes exposed to SO2 were measured.After exposure to SO2,the cytomembrane fluidity of the rat erythrocytes decreased but the level of lipid peroxidation was enhanced.The activities of superoxide dismutase(SOD)、Na+,K+-ATP ase and Ca2+,Mg2+-ATP ase associated with the cytomembrane decreased while the lactate dehydrogenase(LDH) activity in the membrane increased.The results suggest that the components and functions of the plasma membrane were changed and the permeability of the plasma membrane was increased for the rats exposed to SO2.The primary damage resulting from exposure to SO2 was injury to the structure and function of the cytomembrane.
摘要点击次数： 2177 全文下载次数： 2380
