• 关键词：氟虫腈  斑马鱼  菜蛾  急性毒性  手性选择性

• 基金项目：国家自然科学基金项目(No.40873069,40772147)

• 赵琳
• 地表过程分析与模拟教育部重点实验室, 北京大学城市与环境学院, 北京 100871

• 包琛
• 地表过程分析与模拟教育部重点实验室, 北京大学城市与环境学院, 北京 100871

• 杨代斌
• 植物保护研究所, 中国农业科学研究院, 北京 100094

• 李喜青
• 地表过程分析与模拟教育部重点实验室, 北京大学城市与环境学院, 北京 100871

• 摘要：手性农药分子的不同对映体在环境中的降解速率和对于生物的毒性可能存在很大的差异,因此拆分并使用对靶标生物毒性较高或对非靶标生物毒性较低的单一或浓缩的对映体配方可以有效地降低杀虫剂的环境风险.本文用手性柱拆分了一种广泛使用的手性农药,氟虫腈的两种对映体,研究了这两种对映体和消旋体对靶标生物小菜蛾和非靶标生物斑马鱼的急性毒性.结果表明氟虫腈对受试靶标和非靶标生物的毒性均无手性选择性,说明无法通过对氟虫腈进行手性拆分并使用单一对映体配方来降低氟虫腈的环境风险.这一结论间接支持了农业部新近出台的禁止氟虫腈用于防治农田害虫的政策.

• Abstract：The two enantiomers of a chiral pesticide may differ in their degradation kinetics in the environment and their toxicities toward certain species. The enantiomer-specific effects indicate that it would be environmentally friendly to use pesticide formulations with single or enriched enantiomers that are either more active toward target insects or less toxic to non-target species. In this work,the two enantiomers of a chiral pesticide,fipronil,were separated and their toxicities to a target species,diamondback moth,and a non-target species,zebrafish were examined. It was found that fipronil showed no enantioselective toxicity to either the target or the non-target species. As such,using a single or enriched fipronil enantiomer formulation is unlikely to be an effective approach to reduce the risks of fipronil to non-target species. This conclusion indirectly supports the new policy of the Ministry of Agriculture of China to ban the agricultural use of fipronil.

• Key words：fipronil  zebra fish  diamondback moth  acute toxicity  enantioselectivity

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