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研究报告

徐红梅,任娜,宣怡红,丁运生,陈欢欢,张叶,孙妍妍,赵盼盼,张未军.四氟硼酸化1-烷基—3-甲基咪唑离子液体对小鼠的急性经口毒性[J].环境科学学报,2013,33(1):298-303

Acute oral toxicity of ionic liquid 1-alkyl—3-methylimidazoliu tetrafluoborat to mice

基金项目：国家自然科学基金项目(No.50973025);安徽高校省级自然科学研究重点项目(No.KJ2010A263);国家大学生创新性实验项目(No.101035926)

摘要：采用寇式改良法研究了四氟硼酸化1-烷基—3-甲基咪唑离子液体对小鼠的急性毒性,考察了烷基侧链长度对毒性的影响,同时采用HE染色法观察了离子液体对小鼠胃、小肠、大肠、肝和肾组织的损害.结果表明,4种离子液体([C_nmin]BF₄,n=10、12、14、18) 对小鼠的肠、肝、肾等组织均有损伤,其LD₅₀值在56.16～214.18 mg·kg^-1之间,为中等毒性.四氟硼酸化1-烷基—3-甲基咪唑离子液体对小鼠的急性毒性与烷基侧链长度有关,当碳链长度为14时,毒性最强.

Abstract：Karber's modified method was adopted to evaluate the acute toxicity of ionic liquid 1-alkyl-3-methylimidazolium tetrafluoborat [C_nmin]BF₄ (n=10,12,14,18) with varying alkyl chain lengths to mice.The tissues lesion of mouse, such as stomach, small and large intestine, liver and kidney, were observed by hematoxylin-eosin.The results showed that four ILs, including [C₁₀min]BF₄, [C₁₂min]BF₄, [C₁₄min]BF₄ and [C₁₈min]BF₄, all produced damage to intestine, liver and kidney in mice, and the LD₅₀ of ILs ranged from 56.16 to 214.18 mg·kg^-1, indicating a medium toxicity.The acute toxicity of four ILs to mice was related to the length of side chain, and the ILs with the alkyl chain length of fourteen had the strongest toxicity.