许峰,苑华飞,隋孟璋,张亚婷,李坡,刘庆,罗春云,徐红梅.离子液体[C14mim]Br对大鼠亚慢性毒性的初步研究[J].环境科学学报,2020,40(1):299-305
离子液体[C14mim]Br对大鼠亚慢性毒性的初步研究
- Preliminary study on subchronic toxicity of ionic liquid[C14mim]Br in rats
- 基金项目：安徽省自然科学基金面上项目（No.1708085MB51）；合肥工业大学大学生创新性实验项目（No.2017CXCY487）
- 许峰
- 合肥工业大学, 食品与生物工程学院, 药物科学与工程系, 合肥 230009
- 苑华飞
- 合肥工业大学, 食品与生物工程学院, 药物科学与工程系, 合肥 230009
- 隋孟璋
- 合肥工业大学, 食品与生物工程学院, 药物科学与工程系, 合肥 230009
- 张亚婷
- 合肥工业大学, 食品与生物工程学院, 药物科学与工程系, 合肥 230009
- 李坡
- 合肥工业大学, 食品与生物工程学院, 药物科学与工程系, 合肥 230009
- 刘庆
- 合肥工业大学, 食品与生物工程学院, 药物科学与工程系, 合肥 230009
- 罗春云
- 合肥工业大学, 食品与生物工程学院, 药物科学与工程系, 合肥 230009
- 徐红梅
- 合肥工业大学, 食品与生物工程学院, 药物科学与工程系, 合肥 230009
- 摘要：研究了离子液体溴化-1-十四烷基-3-甲基咪唑盐（[C14mim]Br）对大鼠的亚慢性毒性.实验设立3个染毒组（2.5、5、10 mg·kg-1）和1个对照组，对大鼠经口染毒90 d后，分别考察大鼠的体重、血清生化指标、脏体指数、组织形态学的变化.结果表明，与对照组相比，染毒组大鼠的体重增长随着染毒剂量的增加而降低，肝脏/体重系数增大，其血清中碱性磷酸酶（ALP）、丙氨酸氨基转移酶（ALT）、天门冬氨酸转氨酶（AST）、直接胆红素（DBIL）和和球蛋白（GLB）水平均明显升高，A/G（ALB/GLB）、血清总蛋白（TP）值则明显下降.病理检查结果显示，染毒组大鼠的肝脏、肾脏及肺均有不同程度的损伤及病变.研究表明，[C14mim]Br亚慢性染毒对大鼠的肝肾均有损伤，且其毒性呈一定的剂量依赖性.
- Abstract：To investigate the sub-chronic toxicity of ionic liquid bromide 1-tetradecyl-3-methyl imidazole salt ([C14mim]Br) in rats,[C14mim]Br were administered to rats by intra-gastric administration at three different dosages (2.5, 5, 10 mg·kg-1) for 90 days. Also one blank control group (intra-gastric administration with only water) were established in the experiment. Then the changes of body weight, serum biochemical index, visceral body index and histomorphology in rats were investigated. Results:Compared with the blank control group, there showed a decreasing trend of body weight increase in[C14mim]Br groups. And this effect showed in a dose-dependent manner. The ratio of liver to body (the coefficients of liver) was positively related with the[C14mim]Br dosages. The serum levels of ALP, ALT, AST, DBIL and GLB were significantly increased, while A/G, TP values were significantly decreased. The histopathology showed that the liver and kidney tissue in rats with different dosages of[C14mim]Br administration were damaged in different degrees. Conclusion:Sub-chronic exposure to[C14mim]Br could damage the liver and kidney in rats and its toxicity showed in a dose-dependent manner.
