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研究报告

The role of norfloxacin and oxytetracycline on the accumulation and transformation of mercury in vivo of fish

摘要：为阐明诺氟沙星和土霉素对汞（Hg）在鱼体内积累和转化的影响机制，探究了Hg单一暴露、诺氟沙星-Hg和土霉素-Hg复合暴露条件下，鱼体内各器官和组织中总汞（THg）和甲基汞（MeHg）的积累特征.结果表明：Hg单一暴露条件下，鱼体肌肉THg含量随着暴露时间呈先增加后降低的趋势，鱼头和内脏组织的THg含量随暴露时间增加而逐渐增加，内脏组织积累量高于鱼头（p<0.01）.鱼体内的MeHg含量随着暴露时间的增加而不断增加，其中肌肉和内脏组织增加显著（p<0.05），鱼头无明显差异（p>0.05）.在诺氟沙星-Hg和土霉素-Hg复合暴露条件下，鱼体内的THg和MeHg含量与Hg单一暴露处理相比均产生显著变化，诺氟沙星和土霉素均能促进THg在鱼体内的积累及抑制MeHg的形成（p<0.01）.然而，无论对THg积累的促进作用还是对MeHg形成的抑制作用，诺氟沙星比土霉素作用都更为显著.

Abstract：This paper investigated the accumulation characteristics of total mercury （THg） and methylmercury （MeHg） in fish exposed to mercury （Hg） in the absence or presence of norfloxacin or oxytetracycline， in an attempt to illustrate these two antibiotics accumulation on the methylation of mercury （Hg） in vivo of fish. The results showed that THg contents in fish muscle increased at the early stage and then gradually decreased with time when the fish were exposed to single Hg； however， THg in head and visceral mass increased continuously. It was noted that， THg in visceral mass was significantly higher than that in head （p<0.01）. On the other hand， it was observed that the accumulation of MeHg in different fish tissues rose gradually during the culture period， especially in muscle and visceral mass （p<0.05）. However， no significance difference was observed in fish head （p>0.05）. When the fish were exposed to Hg and one of these two antibiotics simultaneously， both THg and MeHg content in fish varied significantly in comparison with sole exposure to Hg. Both norfloxacin and oxytetracycline could promote the accumulation of THg， and but inhibit MeHg formation in fish tissues （p<0.01）. Norfloxacin exhibited stronger effects than oxytetracycline on the promotion of THg accumulation and the inhibition of MeHg formation.